LY395756   Click here for help

GtoPdb Ligand ID: 11614

Synonyms: (±)-LY 395756 | LY 395756 | LY-395756 | LY39
Compound class: Synthetic organic
Comment: LY 395756 is a small molecule that acts as an agonist of mGlu2 receptors and as an antagonist of mGlu3 receptors [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 100.62
Molecular weight 199.08
XLogP -2.88
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES C[C@@H]1C[C@@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(N)C(=O)O
Isomeric SMILES C[C@@H]1C[C@@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(N)C(=O)O
InChI InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4+,5+,6+,9+/m1/s1
InChI Key BQVZICWQBFTOJX-QNDZYWSYSA-N
References
1. Li ML, Yang SS, Xing B, Ferguson BR, Gulchina Y, Li YC, Li F, Hu XQ, Gao WJ. (2015)
LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment.
Exp Neurol, 273: 190-201. [PMID:26341392]