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Synonyms: MP5D2_CL22A3 | UCB-6114
Compound class:
Antibody
Comment: Ginisortamab (UCB6114) is a human IgG4κ monoclonal antibody that targets the endogenous BMP antagonist peptide gremlin 1. The heavy and light chain peptide sequences of ginisortamab are claimed in UCB Biopharma's patent WO2018115017A2 [1].The patent describes their antibodies as allosteric modulators, whose epitope is distal to the BMP binding site of gremlin 1.
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| References |
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1. Dedi N, Twomey B, Wright MJ, Davies G, McMillan DJ. (2018)
Gremlin-1 crystal structure and inhibitory antibody. Patent number: WO2018115017A2. Assignee: UCB Biopharma Sprl. Priority date: 19/12/2016. Publication date: 28/06/2018. |
