Synonyms: CP628006
Compound class:
Synthetic organic
Comment: CP-628006 is a CFTR potentiator [1]. It restores function to the cystic fibrosis CFTR gating variant G551D by increasing the frequency and duration of channel openings.
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References |
1. Liu J, Berg AP, Wang Y, Jantarajit W, Sutcliffe KJ, Stevens EB, Cao L, Pregel MJ, Sheppard DN. (2022)
A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR. Br J Pharmacol, 179 (7): 1319-1337. [PMID:34644413] |