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Compound class:
Peptide or derivative
Comment: This is an INSL5 analogue that has a simplified A-chain connected to the B-chain by two disulfide bonds [1]. Its A-chain peptide sequence is hINSL5: A8-21 (T15K).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Patil NA, Hughes RA, Rosengren KJ, Kocan M, Ang SY, Tailhades J, Separovic F, Summers RJ, Grosse J, Wade JD et al.. (2016)
Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist. J Med Chem, 59 (5): 2118-25. [PMID:26824523] |
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2. Praveen P, Bathgate RAD, Hossain MA. (2019)
Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4. Sci Rep, 9 (1): 17828. [PMID:31780677] |
