RLF-(A11-B10)-isopeptide amideA26 (xA11-B10)   Click here for help

GtoPdb Ligand ID: 11922

Compound class: Peptide or derivative
Comment: RLF-(A11-B10)-isopeptide amideA26 (xA11-B10) is a derivative of relaxin-like factor (RLF/INSL3) in which the interchain disulphide bond is replaced with an isopeptide bond. This derivative behaves as a RXFP2 antagonist (Kd ~2 nM) [1].
References
1. Büllesbach EE, Schwabe C. (2012)
Replacement of disulfides by amide bonds in the relaxin-like factor (RLF/INSL3) reveals a role for the A11-B10 link in transmembrane signaling.
Biochemistry, 51 (20): 4198-205. [PMID:22574850]