Synonyms: L/105 | Rifamycin L 105 | Xifaxan®
rifaximin is an approved drug (FDA (2004))
Compound class:
Synthetic organic
Comment: Rifaximin is a semisynthetic derivative of rifamycin and belongs to the ansamycin group of antibacterial compounds [1]. It has broad spectrum activity against Gram-positive and Gram-negative bacteria.
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References |
1. Brufani M, Cellai L, Cerrini S, Fedeli W, Marchi E, Segre A, Vaciago A. (1984)
X-ray crystal structure of 4-deoxy-3'-bromopyrido[1',2'-1,2]imidazo[5,4-c]rifamycin S. J Antibiot (Tokyo), 37 (12): 1623-7. [PMID:6549316] |
2. Gomi H, Jiang ZD, Adachi JA, Ashley D, Lowe B, Verenkar MP, Steffen R, DuPont HL. (2001)
In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions. Antimicrob Agents Chemother, 45 (1): 212-6. [PMID:11120968] |
3. Hoover WW, Gerlach EH, Hoban DJ, Eliopoulos GM, Pfaller MA, Jones RN. (1993)
Antimicrobial activity and spectrum of rifaximin, a new topical rifamycin derivative. Diagn Microbiol Infect Dis, 16 (2): 111-8. [PMID:8385592] |