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Synonyms: compound 2 [PMID: 24363056] | compound 3 [PMID: 12033947] | N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine
Compound class: Peptide or derivative
Comment: This modified dipeptide is used as an antagonist of the α9β1 and α4β1 integrins functions [1-2]. It is used experimentally as the sodium salt.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Cao B, Hutt OE, Zhang Z, Li S, Heazlewood SY, Williams B, Smith JA, Haylock DN, Savage GP, Nilsson SK. (2014)
Design, synthesis and binding properties of a fluorescent α₉β₁/α₄β₁ integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells.
Org Biomol Chem, 12 (6): 965-78. [PMID:24363056]
2. Pepinsky RB, Mumford RA, Chen LL, Leone D, Amo SE, Riper GV, Whitty A, Dolinski B, Lobb RR, Dean DC et al.. (2002)
Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.
Biochemistry, 41 (22): 7125-41. [PMID:12033947]