Synonyms: CL-092 | compound 8 [WO2019148044A1] [1] | XL-092 | XL092
Compound class:
Synthetic organic
Comment: We obtained the chemical structure for zanzalintinib from the WHO's proposed INN list 127 (21 July 2022). In this document it was described as a tyrosine kinase inhibitor and antineoplastic. The synonym list in PubChem's record for this compound suggests that zanzalintinib is the INN for Exelixis's clinical lead XL092 which is an analogue of cabozantinib [3]. XL092 is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER [2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Bannen LC, Bui M, Jiang F, Tso K, Wang Y, Xu W. (2019)
Compounds for the treatment of kinase-dependent disorders. Patent number: WO2019148044A1. Assignee: Exelixis, Inc.. Priority date: 26/01/2018. Publication date: 01/08/2019. |
2. Hsu J, Chong C, Goon L, Balayan J, Wu S, Johnson E, Lorenzana G, Bannen L, Nguyen L, Scheffold C et al.. (2021)
33 Poster Discussion - XL092, a multi-targeted inhibitor of MET, VEGFR2, AXL and MER with an optimized pharmacokinetic profile. European Journal of Cancer, 138: S16. DOI: 10.1016/S0959-8049(20)31107-2 |
3. Yuan L, Li J, Feng M, Zou XR. (2021)
Identification of the metabolites of XL092 in rat and human by using ultra-high performance liquid chromatography high resolution mass spectrometry. J Pharm Biomed Anal, 206: 114390. [PMID:34600174] |