Synonyms: Compound 5 [WO2020223685A1]
Compound class:
Synthetic organic
Comment: We obtained the chemical structure for acloproxalap from the WHO's proposed INN list 127 (21 July 2022). In this document it was described as an anti-inflammatory. Acloproxalap is an analogue of reproxalap. Like its predecessor, acloproxalap was designed as a molecular trap for pro-inflammatory Reactive Aldehyde Species (RASP) molecules that are produced by metabolic and inflammatory processes, to treat diseases in which aldehyde toxicity is implicated in the pathogenesis [1]. We predict that acloproxalap is the INN for the clinical lead known as ADX-629.
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References |
1. Machatha SG, Montgomery C, Krausert S, Loughrey JJ, McLachlan HR, Sneddon G. (2020)
Polymorphic compounds and uses thereof. Patent number: WO2020223685A1. Assignee: Aldeyra Therapeutics, Inc.. Priority date: 02/05/2019. Publication date: 05/11/2020. |