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Synonyms: compound 40 [PMID: 35500094]
Compound class: Synthetic organic
Comment: NVP-CLR457 is an orally bioavailable inhibitor of Class IA phosphoinositol-3-kinases (PI3Ks) . Inhibitors of this type are being evaluated as an approach to cancer treatment that has predicted application over a broad range of tumour types.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Fairhurst RA, Furet P, Imbach-Weese P, Stauffer F, Rueeger H, McCarthy C, Ripoche S, Oswald S, Arnaud B, Jary A et al.. (2022)
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
J Med Chem, 65 (12): 8345-8379. [PMID:35500094]