KC-180-2   Click here for help

GtoPdb Ligand ID: 12176

Compound class: Synthetic organic
Comment: KC-180-2 is a dual action tubulin polymerisation inhibitor and Src kinase inhibitor that was developed as a refined derivative of the anti-cancer agent tirbanibulin (KX2-391) [1]. Destabilisation of tubulin polymers is the primary mechanism that underlies KC-180-2's effects on cell cycle arrest in cancer cells. KC-180-2 occupies the same non-ATP substrate binding pocket within Src as KX2-391.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 45.23
Molecular weight 357.18
XLogP 4.2
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C(Cc1ccc(cn1)c1ccc(cc1)N1CCC1)NCc1ccccc1
Isomeric SMILES N1(CCC1)c1ccc(cc1)c1ccc(nc1)CC(=O)NCc1ccccc1
InChI InChI=1S/C23H23N3O/c27-23(25-16-18-5-2-1-3-6-18)15-21-10-7-20(17-24-21)19-8-11-22(12-9-19)26-13-4-14-26/h1-3,5-12,17H,4,13-16H2,(H,25,27)
InChI Key KUPDBUBFYCYCNJ-UHFFFAOYSA-N
References
1. Peng J, Zeng Y, Hu X, Huang S, Gao X, Tian D, Tian S, Qiu L, Dong R, Zhan W et al.. (2022)
KC-180-2 Exerts Anti-SCLC Effects via Dual Inhibition of Tubulin Polymerization and Src Signaling.
ACS Omega, Epub ahead of print. DOI: 10.1021/acsomega.2c03408