penpulimab   Click here for help

GtoPdb Ligand ID: 12347

Synonyms: AK-105 | AK105
Approved drug Immunopharmacology Ligand
penpulimab is an approved drug (China (2021))
Compound class: Antibody
Comment: Penpulimab (AK-105) is a chimeric IgG1κ programmed cell death 1 (PD-1) monoclonal antibody [2]. Its engineered Fc structure means that it does not interact with Fcγ receptors and therefore it does not induce immune cell (macrophage) effector functions (antibody-dependent cell-mediated cytotoxicity/ADCC, antibody-dependent cellular phagocytosis/ADCP, antibody-dependent cytokine release/ADCR). Penpulimab binds to an epitope in human PD-1's N-glycosylation site (at residue N58).
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1. Dhillon S. (2021)
Penpulimab: First Approval.
Drugs, 81 (18): 2159-2166. [PMID:34813051]
2. Huang Z, Pang X, Zhong T, Qu T, Chen N, Ma S, He X, Xia D, Wang M, Xia M et al.. (2022)
Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events.
Front Immunol, 13: 924542. [PMID:35833116]