penpulimab   Click here for help

GtoPdb Ligand ID: 12347

Synonyms: AK-105 | AK105
Approved drug Immunopharmacology Ligand
penpulimab is an approved drug (China (2021))
Compound class: Antibody
Comment: Penpulimab (AK-105) is a chimeric IgG1κ programmed cell death 1 (PD-1) monoclonal antibody [2]. Its engineered Fc structure means that it does not interact with Fcγ receptors and therefore it does not induce immune cell (macrophage) effector functions (antibody-dependent cell-mediated cytotoxicity/ADCC, antibody-dependent cellular phagocytosis/ADCP, antibody-dependent cytokine release/ADCR). Penpulimab binds to an epitope in human PD-1's N-glycosylation site (at residue N58).
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Classification Click here for help
Compound class Antibody
Ligand families/groups Immune checkpoint modulators
Approved drug? Yes (China (2021))
International Nonproprietary Names Click here for help
INN number INN
11497 penpulimab
Synonyms Click here for help
AK-105 | AK105
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1093
Other databases
GtoPdb PubChem SID 479821138
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