impentamine

Ligand id: 1252

Name: impentamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 54.7
Molecular weight 153.13
XLogP 0.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Kitbunnadaj R, Zuiderveld OP, De Esch IJ, Vollinga RC, Bakker R, Lutz M, Spek AL, Cavoy E, Deltent MF, Menge WM et al.. (2003)
Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
J. Med. Chem., 46 (25): 5445-57. [PMID:14640553]
2. Wieland K, Bongers G, Yamamoto Y, Hashimoto T, Yamatodani A, Menge WM, Timmerman H, Lovenberg TW, Leurs R. (2001)
Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.
J. Pharmacol. Exp. Ther., 299 (3): 908-14. [PMID:11714875]