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Compound class:
Peptide or derivative
Comment: s-RhTx is an engineered peptide that acts as a positive allosteric modulator of the nociceptive cation channel TRPV1 [1]. It is derived from RhTx, with the 3 N terminal residues removed.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Zhang H, Lin JJ, Xie YK, Song XZ, Sun JY, Zhang BL, Qi YK, Xu ZZ, Yang F. (2023)
Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia. Nat Commun, 14 (1): 4. [PMID:36596769] |
