s-RhTx   Click here for help

GtoPdb Ligand ID: 12546

Comment: s-RhTx is an engineered peptide that acts as a positive allosteric modulator of the nociceptive cation channel TRPV1 [1]. It is derived from RhTx, with the 3 N terminal residues removed.
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPV1 Hs Allosteric modulator Positive 6.1 pEC50 - 1
pEC50 6.1 (EC50 8.9x10-7 M) [1]
Description: Potentiation of the effect of 10 nM capsaicin on channel activity