Synonyms: BI 907828 | BI-907828 | BI907828 | example Ia-34 [WO2017060431A1]
Compound class:
Synthetic organic
Comment: BI 907828 is a small molecule that disrupts the protein-protein interaction between the tumour suppressor p53 and MDM2 (a p53 repressor protein) [1]. Antagonising this interaction is proposed to block proteosomal degradation of p53 protein, which is expected to re-activate p53-mediated induction of tumour cell apoptosis. The chemical structure was disclosed during the 'First Disclosures of New Drug Candidates' session at the April 2023 (Orlando) meeting of the AACR, and it maps to PubChem CID 129264140, and to the proposed INN brigimadlin.
|
|
References |
1. Gollner A, Broeker J, Kerres N, Kofink C, Ramharter J, Weinstabl H, Gille A, Goepper S, Henry M, Huchler G. (2017)
Spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors. Patent number: WO2017060431A1. Assignee: Boehringer Ingelheim International Gmbh. Priority date: 07/10/2016. Publication date: 13/04/2017. |