rolitetracycline   Click here for help

GtoPdb Ligand ID: 12760

Synonyms: pyrrolidinylmethyltetracycline | Reverin® | SQ 15,659 | Syntetrin® | Velacycline®
Approved drug
rolitetracycline is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Rolitetracycline is a parenterally delivered prodrug of tetracycline, an antibacterial that has activity against Gram-negative and Gram-positive bacteria.
Note that the structure shown here matches the CAS-assigned structure and is the same as the ChEBI and ChEMBL entries linked to below. There is no exact match in PubChem for the structure shown here.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 11
Hydrogen bond donors 6
Rotatable bonds 5
Topological polar surface area 170.87
Molecular weight 527.57
XLogP 0.22
No. Lipinski's rules broken 3
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C[C@]1(C2=CC=CC(=C2C(=O)C3=C([C@]4([C@@]([H])(C[C@@]31[H])[C@@H](C(=C(C4=O)C(=O)NCN5CCCC5)O)N(C)C)O)O)O)O
Isomeric SMILES [H][C@@]12C[C@@]3([H])C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(=O)NCN5CCCC5)=C(O)[C@H]2N(C)C
InChI InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1
InChI Key HMEYVGGHISAPJR-IAHYZSEUSA-N
References
1. Gaillard T, Madamet M, Pradines B. (2015)
Tetracyclines in malaria.
Malar J, 14: 445. [PMID:26555664]
2. Pradines B, Rogier C, Fusai T, Mosnier J, Daries W, Barret E, Parzy D. (2001)
In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron.
Antimicrob Agents Chemother, 45 (6): 1746-50. [PMID:11353621]
3. SMITH L. (1964)
ROLITETRACYCLINE, AN ANTIBIOTIC FOR PARENTERAL USE. (SYNTETRIN, VELACYCLINE).
JAMA, 187: 141. [PMID:14066734]