Synonyms: compound 1 [PMID: 33682420] | compound 4 [PMID: 31012583] | GDC0276
Compound class:
Synthetic organic
Comment: GDC-0276 is a voltage-gated sodium ion channel subtype 1.7 (NaV1.7) modulator [1-2]. It was developed as a non-opioid analgesic. It binds to the channel's voltage sensor in domain IV.
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References |
1. Mulcahy JV, Pajouhesh H, Beckley JT, Delwig A, Du Bois J, Hunter JC. (2019)
Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7. J Med Chem, 62 (19): 8695-8710. [PMID:31012583] |
2. Safina BS, McKerrall SJ, Sun S, Chen CA, Chowdhury S, Jia Q, Li J, Zenova AY, Andrez JC, Bankar G et al.. (2021)
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310. J Med Chem, 64 (6): 2953-2966. [PMID:33682420] |