Synonyms: P005672 | Seysara®
sarecycline is an approved drug (FDA (2018))
Compound class:
Synthetic organic
Comment: Sarecycline is a tetracycline antibacterial with narrow-spectrum activity that was developed as an oral anti-acne therapeutic. Note that the structure shown here matches the CAS-assigned structure and is the same as the ChEMBL entry linked to below. The PubChem standardized chemical structure (CID 54681908) for sarecycline is represented with slightly different stereochemistry.
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References |
1. Deeks ED. (2019)
Sarecycline: First Global Approval. Drugs, 79 (3): 325-329. [PMID:30659422] |
2. Lomakin IB, Devarkar SC, Patel S, Grada A, Bunick CG. (2023)
Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Nucleic Acids Res, 51 (6): 2915-2930. [PMID:36864821] |
3. Zhanel G, Critchley I, Lin LY, Alvandi N. (2019)
Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris. Antimicrob Agents Chemother, 63 (1). [PMID:30397052] |