Synonyms: SIM-0417 | SIM0417 | SSD-8432 | SSD8432
simnotrelvir is an approved drug (China NMPA (2023))
Compound class:
Synthetic organic
Comment: Simnotrelvir (SIM0417) is an oral inhibitor of SARS-CoV-2 Mpro [2].
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References |
1. Wang F, Xiao W, Tang Y, Cao M, Shu D, Asakawa T, Xu Y, Jiang X, Zhang L, Wang W et al.. (2023)
Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo-controlled, phase 1b trial. Lancet Reg Health West Pac, 38: 100835. [PMID:37484496] |
2. Zhu KW. (2023)
Deuremidevir and Simnotrelvir-Ritonavir for the Treatment of COVID-19. ACS Pharmacol Transl Sci, 6 (9): 1306-1309. [PMID:37705591] |