prolgolimab   Click here for help

GtoPdb Ligand ID: 12991

Synonyms: BCD-100 | BCD100
Immunopharmacology Ligand
Compound class: Antibody
Comment: Prolgolimab (BCD-100) is a chimeric IgG1 anti-programmed cell death 1 (PD-1) monoclonal antibody [1]. It acts as an inhibitor of the PD-1/PD-L1-PD-L2 inhibitory immune checkpoint. The design of prolgolimab abolishes FcγR binding and therefore Fc-mediated effector functions (antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity).
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1. Ekimova VM, Korzhavin DV, Chernykh YS, Nemankin TA, Solovyev VV, Vladamirova Ak, Bulankina IA, Diduk SV, Ustigov IL, Artiukhova MV et al.. (2021)
Anti-PD-1 antibodies, method for producing same and method for using same.
Patent number: US11136408B2. Assignee: Closed Joint-Stock Co "biocad", Biocad JSC. Priority date: 04/07/2017. Publication date: 05/10/2021.
2. Tjulandin S, Demidov L, Moiseyenko V, Protsenko S, Semiglazova T, Odintsova S, Zukov R, Lazarev S, Makarova Y, Nechaeva M et al.. (2021)
Novel PD-1 inhibitor prolgolimab: expanding non-resectable/metastatic melanoma therapy choice.
Eur J Cancer, 149: 222-232. [PMID:33872982]