Compound class:
Synthetic organic
Comment: TBI-223 is an oxazolidinone class antibacterial with potent antimycobacterial activity. It is being clinically evaluated as a treatment for tuberculosis (TB).
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References |
1. Gordon O, Dikeman DA, Ortines RV, Wang Y, Youn C, Mumtaz M, Orlando N, Zhang J, Patel AM, Gough E et al.. (2022)
The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection. Microbiol Spectr, 10 (5): e0245121. [PMID:36106881] |
2. Li SY, Converse PJ, Betoudji F, Lee J, Mdluli K, Upton A, Fotouhi N, Nuermberger EL. (2023)
Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model. Antimicrob Agents Chemother, 67 (4): e0003523. [PMID:36920217] |
3. Negatu DA, Aragaw WW, Cangialosi J, Dartois V, Dick T. (2023)
Side-by-Side Profiling of Oxazolidinones to Estimate the Therapeutic Window against Mycobacterial Infections. Antimicrob Agents Chemother, 67 (4): e0165522. [PMID:36920191] |