calpurbatug

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Ligands
calpurbatug

GtoPdb Ligand ID: 13036

Synonyms: TRL1068

Comment: Calpurbatug is a fully human monoclonal antibody against members of the DNABII family of bacterial DNA-binding proteins [1-2]. It disrupts bacterial biofilms and is being developed by Trellis Bioscience as a potential treatment in prosthetic joint infections and in chronic rhinosinusitis.
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record.

References
1. Estellés A, Woischnig AK, Liu K, Stephenson R, Lomongsod E, Nguyen D, Zhang J, Heidecker M, Yang Y, Simon RJ et al.. (2016) A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model. Antimicrob Agents Chemother, 60 (4): 2292-301. [PMID:26833157]
2. Xiong YQ, Estellés A, Li L, Abdelhady W, Gonzales R, Bayer AS, Tenorio E, Leighton A, Ryser S, Kauvar LM. (2017) A Human Biofilm-Disrupting Monoclonal Antibody Potentiates Antibiotic Efficacy in Rodent Models of both Staphylococcus aureus and Acinetobacter baumannii Infections. Antimicrob Agents Chemother, 61 (10). [PMID:28717038]

References

1. Estellés A, Woischnig AK, Liu K, Stephenson R, Lomongsod E, Nguyen D, Zhang J, Heidecker M, Yang Y, Simon RJ et al.. (2016)
A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model.
Antimicrob Agents Chemother, 60 (4): 2292-301. [PMID:26833157]

2. Xiong YQ, Estellés A, Li L, Abdelhady W, Gonzales R, Bayer AS, Tenorio E, Leighton A, Ryser S, Kauvar LM. (2017)
A Human Biofilm-Disrupting Monoclonal Antibody Potentiates Antibiotic Efficacy in Rodent Models of both Staphylococcus aureus and Acinetobacter baumannii Infections.
Antimicrob Agents Chemother, 61 (10). [PMID:28717038]