Synonyms: compound #56 [PMID: 38055802] | MS-102
Compound class:
Synthetic organic
Comment: MS102 is a ubiquitin specific peptidase 2 (USP2) inhibitor that was optimised for oral therapeutic use from the lead molecule ML364 [1]. It is proposed as an antiviral agent for infections caused by coronaviruses that use ACE2 for cell entry. Inhibiting USP2 increases ACE2 degradation, thereby reducing potential for infection by ACE2 trophic coronaviruses.
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References |
1. Dang F, Bai L, Dong J, Hu X, Wang J, Paulo JA, Xiong Y, Liang X, Sun Y, Chen Y et al.. (2023)
USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Sci Transl Med, 15 (725): eadh7668. [PMID:38055802] |