Sanofi-14h   Click here for help

GtoPdb Ligand ID: 13067

Synonyms: compound 14h [PMID: 25589934]
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Sanofi-14h is a small molecule inhibitor of AGC family kinases such as the serum/glucocorticoid regulated kinases (SGKs) 1 and 3 [3]. It has also been reported to inhibit STING-mediated TANK binding kinase 1 (TBK1) activation independently of SGK1/3 inhibition [2]. This latter report showed that when STING was activated in macrophages, Sanofi-14h inhibited IFNβ production. Functionally Sanofi-14h's mechanism of action included inhibition of SGK activity in conjunction with disruption of the TBK1/IRF3 pathway downstream of STING activation.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 129.68
Molecular weight 435.29
XLogP 1.03
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=CC(=CC=C1C2=CN=C3C(=NNC3=N2)N)NS(=O)(=O)C4=CC(=CC=C4Cl)Cl
Isomeric SMILES NC1=NNC2=C1N=CC(=N2)C3=CC=C(NS(=O)(=O)C4=CC(Cl)=CC=C4Cl)C=C3
InChI InChI=1S/C17H12Cl2N6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24)
InChI Key RTERCHJCWXQPSS-UHFFFAOYSA-N
References
1. Bago R, Sommer E, Castel P, Crafter C, Bailey FP, Shpiro N, Baselga J, Cross D, Eyers PA, Alessi DR. (2016)
The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.
EMBO J, 35 (17): 1902-22. [PMID:27481935]
2. Castillo Cabrera J, Dang H, Graves A, Zhang Z, Torres-Castillo J, Li K, King Z, Liu P, Aubé J, Bear JE et al.. (2023)
AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms.
Cell Chem Biol, 30 (12): 1601-1616.e6. [PMID:37939709]
3. Halland N, Schmidt F, Weiss T, Saas J, Li Z, Czech J, Dreyer M, Hofmeister A, Mertsch K, Dietz U et al.. (2015)
Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors.
ACS Med Chem Lett, 6 (1): 73-8. [PMID:25589934]