Synonyms: compound 9 [PMID: 38194973] | WD-6305
Compound class:
Synthetic organic
Comment: WD6305 is a heterobifunctional degrader (PROTAC) that targets the RNA methyltransferase METTL3 [1]. It is intended to promote proteasomal degradation of the METTL3-METTL14 methyltransferase complex as an anti-leukemic strategy. The PROTAC engages the Hippel-Lindau (VHL) E3 ligase, and METTL3 is targeted by the small molecule inhibitor UZH2. WD6305 inhibits N6-methyladenosine (m6A) methylation of RNA, and has the effect of reducing proliferation of AML cells. It more efficiently reduces proliferation of AML cells than blocking METTL3 catalytic activity with UZH2.
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References |
1. Du W, Huang Y, Chen X, Deng Y, Sun Y, Yang H, Shi Q, Wu F, Liu G, Huang H et al.. (2024)
Discovery of a PROTAC degrader for METTL3-METTL14 complex. Cell Chem Biol, 31 (1): 177-183.e17. [PMID:38194973] |