Synonyms: compound 19 [PMID: 38316017]
Compound class:
Synthetic organic
Comment: QC-182 is a PROTAC degrader of the structurally related bromodomain-containing histone acetyltransferases E1A binding protein (p300) and CREB binding protein (CBP) [1]. p300 and CBP are therapeutic targets for the development of anti-tumour drugs. QC-182 uses thalidomide as the binding moiety to engage the cereblon E3 ligase complex, and a derivetive of inobrodib (CCS1477) named QC-125 to engage the target proteins.
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References |
1. Chang Q, Li J, Deng Y, Zhou R, Wang B, Wang Y, Zhang M, Huang X, Li Y. (2024)
Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma. J Med Chem, 67 (4): 2466-2486. [PMID:38316017] |