TXA709   Click here for help

GtoPdb Ligand ID: 13160

Compound class: Synthetic organic
Comment: TXA709 is an orally bioavailable prodrug of TXA707 (PubChem: 90135655), a benzamide antibacterial compound that inhibits the essential and conserved prokaryotic cell division protein FtsZ [3]. TXA709 is under clinical development, as a combination therapy with synergistic drug partners, for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) [1-2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 108.66
Molecular weight 514.47
XLogP 1.84
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN1CCC(CC1)C(=O)NC(=O)C2=C(C(=CC=C2F)OCC3=NC4=C(N=CC(=C4)C(F)(F)F)S3)F
Isomeric SMILES CN1CCC(CC1)C(=O)NC(=O)C2=C(C=CC(=C2F)OCC3=NC4=C(S3)N=CC(=C4)C(F)(F)F)F
InChI InChI=1S/C22H19F5N4O3S/c1-31-6-4-11(5-7-31)19(32)30-20(33)17-13(23)2-3-15(18(17)24)34-10-16-29-14-8-12(22(25,26)27)9-28-21(14)35-16/h2-3,8-9,11H,4-7,10H2,1H3,(H,30,32,33)
InChI Key LOTYKTRNFDRNAY-UHFFFAOYSA-N
References
1. Kaul M, Ferrer-González E, Mark L, Parhi AK, LaVoie EJ, Pilch DS. (2022)
Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus.
Med Chem Res, 31 (10): 1705-1715. [PMID:37065467]
2. Kaul M, Mark L, Parhi AK, LaVoie EJ, Pilch DS. (2016)
Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus.
Antimicrob Agents Chemother, 60 (7): 4290-6. [PMID:27161635]
3. Kaul M, Mark L, Zhang Y, Parhi AK, Lyu YL, Pawlak J, Saravolatz S, Saravolatz LD, Weinstein MP, LaVoie EJ et al.. (2015)
TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.
Antimicrob Agents Chemother, 59 (8): 4845-55. [PMID:26033735]
4. Taxis Pharmaceuticals. 
Our Pipeline.
Accessed on 22/03/2024. Modified on 22/03/2024. https://www.taxispharma.com/research-development/our-pipeline/