Compound class:
Natural product or derivative
Comment: Aristoteline is an alkaloid found in the traditional herbal remedy made from Aristotelia chilensis (maqui) leaves. Experimental evidence from assays with NaV1.8 suggests that Aristoteline might act as a NaV channel blocker. Blockade of this periperhal ion channel may contribute to the analgesic activity of Aristoteline-containing extracts.
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References |
1. Pérez R, Figueredo C, Burgos V, Cabrera-Pardo JR, Schmidt B, Heydenreich M, Koch A, Deuis JR, Vetter I, Paz C. (2023)
Natural Compounds Purified from the Leaves of Aristotelia chilensis: Makomakinol, a New Alkaloid and the Effect of Aristoteline and Hobartine on NaV Channels. Int J Mol Sci, 24 (21). [PMID:37958488] |