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Compound class:
Peptide or derivative
Comment: This small peptide is a component of the venom produced by male duck-billed platypus (Ornithorhynchus anatinus [3]). It corresponds to a seven amino acid N-terminal linear fragment of Ornithorhynchus venom C-type natriuretic peptide (P84715) [1-2]. Ornithorhynchus venom causes immediate acute pain in humans that transforms to sustained hyperalgesia.
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| References |
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1. de Plater GM, Martin RL, Milburn PJ. (1998)
A C-type natriuretic peptide from the venom of the platypus (Ornithorhynchus anatinus): structure and pharmacology. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 120 (1): 99-110. [PMID:9827022] |
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2. de Plater GM, Martin RL, Milburn PJ. (1998)
The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release. Toxicon, 36 (6): 847-57. [PMID:9663691] |
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3. Hodgson WC. (1997)
Pharmacological action of Australian animal venoms. Clin Exp Pharmacol Physiol, 24 (1): 10-7. [PMID:9043799] |
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4. Kita M, Black DS, Ohno O, Yamada K, Kigoshi H, Uemura D. (2009)
Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells. J Am Chem Soc, 131 (50): 18038-9. [PMID:19928958] |
