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Compound class:
Peptide or derivative
Comment: T20K (or [T20K]kB1) is a synthetic version of the plant-derived cyclotide cyclotide kalata B1. Compared to the natural cyclotide T20K has a Thr20Lys substitution. It is in preclinical development as an immunomodulator with potential application as a treatment for MS [1].
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| References |
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1. Gründemann C, Stenberg KG, Gruber CW. (2019)
T20K: an immunomodulatory cyclotide on its way to the clinic. Int. J. Pept. Res. Ther, 25: 9-13. DOI: 10.1007/s10989-018-9701-1 |
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2. Muratspahić E, Tomašević N, Nasrollahi-Shirazi S, Gattringer J, Emser FS, Freissmuth M, Gruber CW. (2021)
Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling. J Nat Prod, 84 (8): 2238-2248. [PMID:34308635] |
