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Compound class:
Peptide or derivative
Comment: T20K (or [T20K]kB1) is a synthetic version of the plant-derived cyclotide cyclotide kalata B1. Compared to the natural cyclotide T20K has a Thr20Lys substitution. It is in preclinical development as an immunomodulator with potential application as a treatment for MS [1].
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Peptide Sequence  |
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| cyclo-CGETCVGGTCNTPGCKCSWPVCTRNGLPV | |
| Chemical Modification | |
| Cyclotide with a cyclic cystine knot formed by three disulfide bonds (at Cys5-Cys19, Cys9-Cys21, Cys14-Cys26); cyclized Gly1-Asn29 | |
