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Synonyms: Aβ(1-16) | N-Aβ
Compound class:
Peptide or derivative
Comment: This is a 16 amino acid N-terminal fragment of amyloid β (Aβ) that is found in human cerebrospinal fluid [3-4]. The C-terminal lysine is is rapidly removed by carboxypeptidase, so the 15-mer is more abundant than the 16-mer. It is proposed that this truncated form of Aβ can block the neuronal instability caused by oligomeric Aβ1-42 that is mediated via interactions with α7-containing nicotinic acetylcholine receptors (nAChR), and that this mechanism may offer potential against memory loss in Aβ-associated neurodegenarative disease.
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| References |
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1. Forest KH, Taketa R, Arora K, Todorovic C, Nichols RA. (2021)
The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model. Front Mol Neurosci, 14: 576038. [PMID:33912008] |
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2. Lawrence JL, Tong M, Alfulaij N, Sherrin T, Contarino M, White MM, Bellinger FP, Todorovic C, Nichols RA. (2014)
Regulation of presynaptic Ca2+, synaptic plasticity and contextual fear conditioning by a N-terminal β-amyloid fragment. J Neurosci, 34 (43): 14210-8. [PMID:25339735] |
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3. Portelius E, Price E, Brinkmalm G, Stiteler M, Olsson M, Persson R, Westman-Brinkmalm A, Zetterberg H, Simon AJ, Blennow K. (2011)
A novel pathway for amyloid precursor protein processing. Neurobiol Aging, 32 (6): 1090-8. [PMID:19604603] |
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4. Portelius E, Tran AJ, Andreasson U, Persson R, Brinkmalm G, Zetterberg H, Blennow K, Westman-Brinkmalm A. (2007)
Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry. J Proteome Res, 6 (11): 4433-9. [PMID:17927230] |
