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Synonyms: Aβ(1-16) | N-Aβ
Compound class:
Peptide or derivative
Comment: This is a 16 amino acid N-terminal fragment of amyloid β (Aβ) that is found in human cerebrospinal fluid [3-4]. The C-terminal lysine is is rapidly removed by carboxypeptidase, so the 15-mer is more abundant than the 16-mer. It is proposed that this truncated form of Aβ can block the neuronal instability caused by oligomeric Aβ1-42 that is mediated via interactions with α7-containing nicotinic acetylcholine receptors (nAChR), and that this mechanism may offer potential against memory loss in Aβ-associated neurodegenarative disease.
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Peptide Sequence  |
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| DAEFRHDSGYEVHHQK | |
| H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-OH | |
