Compound class:
Natural product or derivative
Comment: Safranal is a plant-derived bioactive flavonoid compound. Molecular docking indicates that safranal interacts with the orthosteric binding site of serotonin 5-HT1A and 5-HT2A receptors [1]. In vivo, it reduces symptoms of depression and anxiety in rodents.
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References |
1. Amin F, Ibrahim MAA, Rizwan-Ul-Hasan S, Khaliq S, Gabr GA, Muhammad, Khan A, Sidhom PA, Tikmani P, Shawky AM et al.. (2022)
Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis. Molecules, 27 (24). [PMID:36557792] |