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Synonyms: 6-OH-melatonin | 6-OH-MLT
Compound class: Synthetic organic
Comment: One of the metabolites of the approved drug melatonin.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Beresford IJ, Browning C, Starkey SJ, Brown J, Foord SM, Coughlan J, North PC, Dubocovich ML, Hagan RM. (1998)
GR196429: a nonindolic agonist at high-affinity melatonin receptors.
J. Pharmacol. Exp. Ther., 285 (3): 1239-45. [PMID:9618428]
2. Browning C, Beresford I, Fraser N, Giles H. (2000)
Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors.
Br. J. Pharmacol., 129 (5): 877-86. [PMID:10696085]
3. Dubocovich ML. (1985)
Characterization of a retinal melatonin receptor.
J. Pharmacol. Exp. Ther., 234 (2): 395-401. [PMID:2991499]
4. Dubocovich ML, Masana MI, Iacob S, Sauri DM. (1997)
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor.
Naunyn Schmiedebergs Arch. Pharmacol., 355 (3): 365-75. [PMID:9089668]