MAP4   Click here for help

GtoPdb Ligand ID: 1414

Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 130.66
Molecular weight 197.05
XLogP -4.31
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)C(CCP(=O)(O)O)(N)C
Isomeric SMILES OC(=O)[C@](CCP(=O)(O)O)(N)C
InChI InChI=1S/C5H12NO5P/c1-5(6,4(7)8)2-3-12(9,10)11/h2-3,6H2,1H3,(H,7,8)(H2,9,10,11)/t5-/m0/s1
1. Han G, Hampson DR. (1999)
Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor.
J Biol Chem, 274 (15): 10008-13. [PMID:10187777]
2. Peltekova V, Han G, Soleymanlou N, Hampson DR. (2000)
Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors.
Brain Res Mol Brain Res, 76 (1): 180-90. [PMID:10719229]
3. Pin JP, Acher F. (2002)
The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.
Curr Drug Targets CNS Neurol Disord, 1 (3): 297-317. [PMID:12769621]
4. Saugstad JA, Kinzie JM, Shinohara MM, Segerson TP, Westbrook GL. (1997)
Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile.
Mol Pharmacol, 51 (1): 119-25. [PMID:9016353]
5. Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. (2000)
Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.
Naunyn Schmiedebergs Arch Pharmacol, 362 (6): 546-54. [PMID:11138847]