MPEP   Click here for help

GtoPdb Ligand ID: 1426

Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 12.89
Molecular weight 193.09
XLogP 3.77
No. Lipinski's rules broken 0
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Canonical SMILES Cc1cccc(n1)C#Cc1ccccc1
Isomeric SMILES Cc1cccc(n1)C#Cc1ccccc1
InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
1. Gasparini F, Andres H, Flor PJ, Heinrich M, Inderbitzin W, Lingenhöhl K, Müller H, Munk VC, Omilusik K, Stierlin C et al.. (2002)
[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.
Bioorg Med Chem Lett, 12 (3): 407-9. [PMID:11814808]
2. Gasparini F, Lingenhöhl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S et al.. (1999)
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
Neuropharmacology, 38 (10): 1493-503. [PMID:10530811]
3. Mathiesen JM, Svendsen N, Bräuner-Osborne H, Thomsen C, Ramirez MT. (2003)
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Br J Pharmacol, 138 (6): 1026-30. [PMID:12684257]