Compound class:
Endogenous peptide in human, mouse or rat
Comment: The amino acid sequences of human and porcine motlin are the same. As with many peptide ligands there is some ambiguity in the literature and on online resources as to the exact stereochemistry of motilin. The structure shown here matches that in the PubChem and ChEMBL entries linked to above.
Species: Human, Pig
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: motilin |
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References |
1. Coulie B, Matsuura B, Dong M, Hadac EM, Pinon DI, Feighner SD, Howard AD, Miller LJ. (2001)
Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J Biol Chem, 276 (38): 35518-22. [PMID:11461914] |
2. Matsuura B, Dong M, Coulie B, Pinon DI, Miller LJ. (2005)
Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog. J Pharmacol Exp Ther, 313 (3): 1101-8. [PMID:15677347] |
3. Matsuura B, Dong M, Miller LJ. (2002)
Differential determinants for peptide and non-peptidyl ligand binding to the motilin receptor. Critical role of second extracellular loop for peptide binding and action. J Biol Chem, 277 (12): 9834-9. [PMID:11781320] |
4. Matsuura B, Dong M, Naik S, Miller LJ, Onji M. (2006)
Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity. J Biol Chem, 281 (18): 12390-6. [PMID:16531413] |