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Synonyms: GM 109 | GM109
Compound class: Peptide or derivative
Comment: Circular peptide. Note that the ChEMBL link above displays the non-chiral chemical structure.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Clark MJ, Wright T, Bertrand PP, Bornstein JC, Jenkinson KM, Verlinden M, Furness JB. (1999)
Erythromycin derivatives ABT 229 and GM 611 act on motilin receptors in the rabbit duodenum.
Clin Exp Pharmacol Physiol, 26 (3): 242-5. [PMID:10081621]
2. Haramura M, Okamachi A, Tsuzuki K, Yogo K, Ikuta M, Kozono T, Takanashi H, Murayama E. (2002)
Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin.
J Med Chem, 45 (3): 670-5. [PMID:11806718]
3. Takanashi H, Yogo K, Ozaki K, Ikuta M, Akima M, Koga H, Nabata H. (1995)
GM-109: a novel, selective motilin receptor antagonist in the smooth muscle of the rabbit small intestine.
J Pharmacol Exp Ther, 273 (2): 624-8. [PMID:7752063]