GM-109   Click here for help

GtoPdb Ligand ID: 1466

Synonyms: GM 109 | GM109
Comment: Circular peptide. Note that the ChEMBL link above displays the non-chiral chemical structure.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Click here for help
Canonical SMILES O=C1NCCCCC(NC(=O)C(Cc2ccccc2)N)C(=O)NC(C(=O)NCC1)Cc1ccc(c(c1)C(C)(C)C)O
Isomeric SMILES O=C1NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)N)C(=O)N[C@H](C(=O)NCC1)Cc1ccc(c(c1)C(C)(C)C)O
InChI InChI=1S/C31H43N5O5/c1-31(2,3)22-17-21(12-13-26(22)37)19-25-29(40)34-16-14-27(38)33-15-8-7-11-24(30(41)36-25)35-28(39)23(32)18-20-9-5-4-6-10-20/h4-6,9-10,12-13,17,23-25,37H,7-8,11,14-16,18-19,32H2,1-3H3,(H,33,38)(H,34,40)(H,35,39)(H,36,41)/t23-,24-,25-/m0/s1
1. Clark MJ, Wright T, Bertrand PP, Bornstein JC, Jenkinson KM, Verlinden M, Furness JB. (1999)
Erythromycin derivatives ABT 229 and GM 611 act on motilin receptors in the rabbit duodenum.
Clin Exp Pharmacol Physiol, 26 (3): 242-5. [PMID:10081621]
2. Haramura M, Okamachi A, Tsuzuki K, Yogo K, Ikuta M, Kozono T, Takanashi H, Murayama E. (2002)
Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin.
J Med Chem, 45 (3): 670-5. [PMID:11806718]
3. Takanashi H, Yogo K, Ozaki K, Ikuta M, Akima M, Koga H, Nabata H. (1995)
GM-109: a novel, selective motilin receptor antagonist in the smooth muscle of the rabbit small intestine.
J Pharmacol Exp Ther, 273 (2): 624-8. [PMID:7752063]