Ligand id: 1485

Name: BIBP3226

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 5
Rotatable bonds 13
Topological polar surface area 142.83
Molecular weight 473.24
XLogP 3.15
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Bonini JA, Jones KA, Adham N, Forray C, Artymyshyn R, Durkin MM, Smith KE, Tamm JA, Boteju LW, Lakhlani PP et al.. (2000)
Identification and characterization of two G protein-coupled receptors for neuropeptide FF.
J. Biol. Chem., 275 (50): 39324-31. [PMID:11024015]
2. Doods HN, Wienen W, Entzeroth M, Rudolf K, Eberlein W, Engel W, Wieland HA. (1995)
Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226.
J. Pharmacol. Exp. Ther., 275 (1): 136-42. [PMID:7562541]
3. Gehlert DR, Schober DA, Gackenheimer SL, Beavers L, Gadski R, Lundell I, Larhammar D. (1997)
[125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Peptides, 18 (3): 397-401. [PMID:9145427]
4. Gouardères C, Quelven I, Mollereau C, Mazarguil H, Rice SQ, Zajac JM. (2002)
Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands.
Neuroscience, 115 (2): 349-61. [PMID:12421602]
5. Holliday ND, Cox HM. (1996)
The functional investigation of a human adenocarcinoma cell line, stably transfected with the neuropeptide Y Y1 receptor.
Br. J. Pharmacol., 119 (2): 321-9. [PMID:8886416]
6. Mollereau C, Gouardères C, Dumont Y, Kotani M, Detheux M, Doods H, Parmentier M, Quirion R, Zajac JM. (2001)
Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226.
Br. J. Pharmacol., 133 (1): 1-4. [PMID:11325787]
7. Mollereau C, Mazarguil H, Marcus D, Quelven I, Kotani M, Lannoy V, Dumont Y, Quirion R, Detheux M, Parmentier M et al.. (2002)
Pharmacological characterization of human NPFF(1) and NPFF(2) receptors expressed in CHO cells by using NPY Y(1) receptor antagonists.
Eur. J. Pharmacol., 451 (3): 245-56. [PMID:12242085]
8. Wieland HA, Willim KD, Entzeroth M, Wienen W, Rudolf K, Eberlein W, Engel W, Doods HN. (1995)
Subtype selectivity and antagonistic profile of the nonpeptide Y1 receptor antagonist BIBP 3226.
J. Pharmacol. Exp. Ther., 275 (1): 143-9. [PMID:7562543]