pancreatic polypeptide   Click here for help

GtoPdb Ligand ID: 1512

Abbreviated name: PP
Compound class: Endogenous peptide in human, mouse or rat
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: pancreatic polypeptide

References
1. Bard JA, Walker MW, Branchek TA, Weinshank RL. (1995)
Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.
J Biol Chem, 270 (45): 26762-5. [PMID:7592911]
2. Dumont Y, Thakur M, Beck-Sickinger A, Fournier A, Quirion R. (2003)
Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Br J Pharmacol, 139 (7): 1360-8. [PMID:12890716]
3. Gehlert DR, Schober DA, Gackenheimer SL, Beavers L, Gadski R, Lundell I, Larhammar D. (1997)
[125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Peptides, 18 (3): 397-401. [PMID:9145427]
4. Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J et al.. (1996)
Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
J Biol Chem, 271 (42): 26315-9. [PMID:8824284]
5. Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D. (1995)
Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
J Biol Chem, 270 (49): 29123-8. [PMID:7493937]
6. Tough IR, Holliday ND, Cox HM. (2006)
Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
J Pharmacol Exp Ther, 319 (1): 20-30. [PMID:16807358]
7. Walker MW, Smith KE, Bard J, Vaysse PJ, Gerald C, Daouti S, Weinshank RL, Branchek TA. (1997)
A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Peptides, 18 (4): 609-12. [PMID:9210181]
8. Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W. (1996)
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
Proc Natl Acad Sci USA, 93 (10): 4661-5. [PMID:8643460]