nicotinic acid

Ligand id: 1588

Name: nicotinic acid

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 50.19
Molecular weight 123.03
XLogP 0.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Soga T, Kamohara M, Takasaki J, Matsumoto S, Saito T, Ohishi T, Hiyama H, Matsuo A, Matsushime H, Furuichi K. (2003)
Molecular identification of nicotinic acid receptor.
Biochem. Biophys. Res. Commun., 303 (1): 364-9. [PMID:12646212]
2. Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S. (2003)
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.
Nat. Med., 9 (3): 352-5. [PMID:12563315]
3. Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A et al.. (2003)
Molecular identification of high and low affinity receptors for nicotinic acid.
J. Biol. Chem., 278 (11): 9869-74. [PMID:12522134]