endomorphin-1   Click here for help

GtoPdb Ligand ID: 1623

Comment: The amino acid sequence of endomorphin-1 is believed to be common across mammalian species [3].

An endogenous peptide, the gene encoding the endomorphin precursor has not yet been identified [2].
Species: Human
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2D Structure
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Canonical SMILES Oc1ccc(cc1)CC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)N
Isomeric SMILES Oc1ccc(cc1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)N
InChI InChI=1S/C34H38N6O5/c35-26(17-22-12-14-24(41)15-13-22)34(45)40-16-6-11-30(40)33(44)39-29(19-23-20-37-27-10-5-4-9-25(23)27)32(43)38-28(31(36)42)18-21-7-2-1-3-8-21/h1-5,7-10,12-15,20,26,28-30,37,41H,6,11,16-19,35H2,(H2,36,42)(H,38,43)(H,39,44)/t26-,28-,29-,30-/m0/s1
1. Gong J, Strong JA, Zhang S, Yue X, DeHaven RN, Daubert JD, Cassel JA, Yu G, Mansson E, Yu L. (1998)
Endomorphins fully activate a cloned human mu opioid receptor.
FEBS Lett, 439 (1-2): 152-6. [PMID:9849897]
2. Rónai AZ, Király K, Szebeni A, Szemenyei E, Prohászka Z, Darula Z, Tóth G, Till I, Szalay B, Kató E et al.. (2009)
Immunoreactive endomorphin 2 is generated extracellularly in rat isolated L4,5 dorsal root ganglia by DPP-IV.
Regul Pept, 157 (1-3): 1-2. [PMID:19540879]
3. Zadina JE, Hackler L, Ge LJ, Kastin AJ. (1997)
A potent and selective endogenous agonist for the mu-opiate receptor.
Nature, 386 (6624): 499-502. [PMID:9087409]