endomorphin-1   Click here for help

GtoPdb Ligand ID: 1623

Comment: The amino acid sequence of endomorphin-1 is believed to be common across mammalian species [3].

An endogenous peptide, the gene encoding the endomorphin precursor has not yet been identified [2].
Species: Human
Click here for help
2D Structure
Click here for help
Click here for structure editor
Click here for help
Canonical SMILES Oc1ccc(cc1)CC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)N
Isomeric SMILES Oc1ccc(cc1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)N
InChI InChI=1S/C34H38N6O5/c35-26(17-22-12-14-24(41)15-13-22)34(45)40-16-6-11-30(40)33(44)39-29(19-23-20-37-27-10-5-4-9-25(23)27)32(43)38-28(31(36)42)18-21-7-2-1-3-8-21/h1-5,7-10,12-15,20,26,28-30,37,41H,6,11,16-19,35H2,(H2,36,42)(H,38,43)(H,39,44)/t26-,28-,29-,30-/m0/s1
Natural/Endogenous Targets
δ receptor
μ receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
μ receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.3 pKi - 1,3
pKi 8.3 (Ki 5.01x10-9 M) [1,3]
δ receptor Ligand is endogenous in the given species Hs Agonist Full agonist 6.1 pKi - 1
pKi 6.1 [1]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields