Synonyms: (-)naltrexone | naltrexone HCl | ReVia®
naltrexone is an approved drug (FDA (1998), UK (2011))
Compound class:
Synthetic organic
Comment: This is the active isomer of naltrexone. The (+) isomer is inactive at the opioid receptors.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: naltrexone |
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References |
1. Kelly E, Mundell SJ, Sava A, Roth AL, Felici A, Maltby K, Nathan PJ, Bullmore ET, Henderson G. (2015)
The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Psychopharmacology (Berl.), 232 (1): 305-14. [PMID:24973897] |
2. Payza K. (2003)
Binding and activity of opioid ligands at the cloned human delta, mu and kappa receptors. In The Delta Receptor Edited by Chang KJ (CRC Press) 261-275. [ISBN:0824740319] |
3. Raynor K, Kong H, Chen Y, Yasuda K, Yu L, Bell GI, Reisine T. (1994)
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol, 45 (2): 330-4. [PMID:8114680] |
4. Simonin F, Gavériaux-Ruff C, Befort K, Matthes H, Lannes B, Micheletti G, Mattéi MG, Charron G, Bloch B, Kieffer B. (1995)
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc Natl Acad Sci USA, 92 (15): 7006-10. [PMID:7624359] |
5. Toll L, Berzetei-Gurske IP, Polgar WE, Brandt SR, Adapa ID, Rodriguez L, Schwartz RW, Haggart D, O'Brien A, White A et al.. (1998)
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA Res Monogr, 178: 440-66. [PMID:9686407] |
6. Yasuda K, Raynor K, Kong H, Breder CD, Takeda J, Reisine T, Bell GI. (1993)
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci USA, 90 (14): 6736-40. [PMID:8393575] |