Ligand id: 1728

Name: suramin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 29
Hydrogen bond donors 12
Rotatable bonds 22
Topological polar surface area 534.03
Molecular weight 1296.05
XLogP 0.91
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

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Pharmacological characterization of the human P2Y13 receptor.
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Mol Autism, 6: 1. [PMID:25705365]
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Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model.
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10. Schachter JB, Harden TK. (1997)
An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor.
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13. Wolner I, Kassack MU, Ullmann H, Karel A, Hohenegger M. (2005)
Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676.
Br. J. Pharmacol., 146 (4): 525-33. [PMID:16056233]