[111In]DOTA-NOC   Click here for help

GtoPdb Ligand ID: 2045

Synonyms: [111In-DOTA]-NOC [1] | [InIII-DOTA]-NOC | [InIII-DOTA]-NOC
 Ligand is labelled  Ligand is radioactive
Compound class: Peptide
Comment: Synthetic radiolabelled peptide. The amino acid sequence of octreotide (FCFWKTCT) is modified by replacing the phenylalanine residue at position 3 with 3-naphthylalanine. The peptide is conjugated with DOTA (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) and radiolabelled with indium (111I). The structure of the unlabelled form of this peptide is shown in the reference.
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References
1. Ginj M, Chen J, Walter MA, Eltschinger V, Reubi JC, Maecke HR. (2005)
Preclinical evaluation of new and highly potent analogues of octreotide for predictive imaging and targeted radiotherapy.
Clin Cancer Res, 11 (3): 1136-45. [PMID:15709181]
2. Wild D, Schmitt JS, Ginj M, Mäcke HR, Bernard BF, Krenning E, De Jong M, Wenger S, Reubi JC. (2003)
DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals.
Eur J Nucl Med Mol Imaging, 30 (10): 1338-47. [PMID:12937948]