[111In]DOTA-NOC   Click here for help

GtoPdb Ligand ID: 2045

Synonyms: [111In-DOTA]-NOC [1] | [InIII-DOTA]-NOC | [InIII-DOTA]-NOC
 Ligand is labelled  Ligand is radioactive
Compound class: Peptide
Comment: Synthetic radiolabelled peptide. The amino acid sequence of octreotide (FCFWKTCT) is modified by replacing the phenylalanine residue at position 3 with 3-naphthylalanine. The peptide is conjugated with DOTA (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) and radiolabelled with indium (111I). The structure of the unlabelled form of this peptide is shown in the reference.
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
SST2 receptor Hs Agonist Full agonist 8.5 pIC50 - 2
pIC50 8.5 [2]
SST3 receptor Hs Agonist Full agonist 8.1 pIC50 - 2
pIC50 8.1 [2]
SST5 receptor Hs Agonist Full agonist 8.0 pIC50 - 2
pIC50 8.0 [2]